MovDisordV3, Main, Exploration, bibRecord, 000E87

Animal Models of Parkinson’s Disease: limits and relevance to neuroprotection studies

Identifieur interne : 000E87 ( Main/Exploration ); précédent : 000E86; suivant : 000E88

Animal Models of Parkinson’s Disease: limits and relevance to neuroprotection studies

Auteurs : Erwan Bezard [France] ; Zhenyu Yue [États-Unis] ; Deniz Kirik [Suède] ; Maria Grazia Spillantini [Royaume-Uni]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2012.

RBID : PMC:3517687

English descriptors

KwdEn :
- Animals, Disease Models, Animal, Genetic Vectors (adverse effects), Humans, Mice, Mice, Transgenic, Mutation (genetics), Neuroprotective Agents (therapeutic use), Neurotoxins (toxicity), Parkinson Disease (drug therapy), Parkinson Disease (etiology), Protein-Serine-Threonine Kinases (genetics), alpha-Synuclein (genetics).
MESH :
- chemical , genetics : Protein-Serine-Threonine Kinases, alpha-Synuclein.
- chemical , therapeutic use : Neuroprotective Agents.
- adverse effects : Genetic Vectors.
- drug therapy : Parkinson Disease.
- etiology : Parkinson Disease.
- genetics : Mutation.
- chemical , toxicity : Neurotoxins.
- Animals, Disease Models, Animal, Humans, Mice, Mice, Transgenic.

Abstract

Summary

Over the last two decades significant strides has been made towards acquiring a better knowledge of both the aetiology and pathogenesis of Parkinson’s disease (PD). Experimental models are of paramount importance to obtain greater insights into the pathogenesis of the disease. Thus far, neurotoxin-based animal models have been the most popular tools employed to produce selective neuronal death in both in vitro and in vivo systems. These models have been commonly referred to as the pathogenic models. The current trend in modelling PD revolves around what can be called the disease gene-based models, or etiologic models. The value of utilizing multiple models with different mechanism of insult rests on the premise that dopamine (DA) producing neurons die by stereotyped cascades that can be activated by a range of insults, from neurotoxins to down-regulation and overexpression of disease-related genes. In this position paper, we present the relevance of both pathogenic and etiologic models as well as the concept of clinically relevant designs that we argue should be utilized in the pre-clinical development phase of new neuroprotective therapies before embarking into clinical trials.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517687

DOI: 10.1002/mds.25108
PubMed: 22753348
PubMed Central: 3517687

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p id="P2">Over the last two decades significant strides has been made towards acquiring a better knowledge of both the aetiology and pathogenesis of Parkinson’s disease (PD). Experimental models are of paramount importance to obtain greater insights into the pathogenesis of the disease. Thus far, neurotoxin-based animal models have been the most popular tools employed to produce selective neuronal death in both <italic>in vitro</italic>
 and <italic>in vivo</italic>
 systems. These models have been commonly referred to as the <italic>pathogenic</italic>
 models. The current trend in modelling PD revolves around what can be called the <italic>disease gene-based</italic>
 models, or <italic>etiologic</italic>
 models. The value of utilizing multiple models with different mechanism of insult rests on the premise that dopamine (DA) producing neurons die by stereotyped cascades that can be activated by a range of insults, from neurotoxins to down-regulation and overexpression of disease-related genes. In this position paper, we present the relevance of both pathogenic and etiologic models as well as the concept of clinically relevant designs that we argue should be utilized in the pre-clinical development phase of new neuroprotective therapies before embarking into clinical trials.</p>
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Movement Disorders (revue)

Animal Models of Parkinson’s Disease: limits and relevance to neuroprotection studies

Animal Models of Parkinson’s Disease: limits and relevance to neuroprotection studies

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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	Movement Disorders (revue)
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